The COMprehensive Protein Allergen REsource is a new comprehensive repository of protein sequences of known or putative allergens. It was created via the development of an automated “rule-based” sorting algorithm tool, combined with a review of the literature associated with the identified sequences. An independent peer-review panel of allergy experts exclusively from the public sector decides on the final content of the database. These three rigorous and well-documented processes have been carefully designed to meet the needs for allergy safety assessment. The combination of these three processes results in the COMPARE database which includes a comprehensive repository of all known allergens from past versions, with the addition of allergens newly identified within the 1-year time window covering each annual update. This approach is designed to:
1) Establish a process to identify new listings of candidate allergen sequences.
2) Identify published literature linked to the identified potential allergens.
3) Verify that the newly identified sequences have clinical evidence of allergenicity based on standardized criteria.
The COMPARE database is a collaborative effort of the HESI (Health and Environmental Sciences Institute) Protein Allergens, Toxins and Bioinformatics (PATB) committee (formerly “Protein Allergenicity Technical Committee” or PATC). The PATB is a public-private collaboration of scientists with a shared interest in improving the assessment of allergenicity in the context of safety evaluation of novel food and feed proteins.
The COMPARE steering team combines programmatic support from the Joint Institute for Food Safety and Nutrition (http://jifsan.umd.edu) at the University of Maryland, and significant in-kind support from multiple academic, government and industry scientists with expertise in protein allergenicity. This public-private HESI collaborative team has documented the database design and search algorithm decisions on this website.
The Peer Review Panel is an external expert panel comprised of public-sector reviewers only, who convene to review protein sequences identified as potential allergens and evaluate associated peer-reviewed publications to determine if the allergen candidates meet criteria for inclusion in the database. In a fully transparent manner, the expert panel documents the supporting data for each verified allergen and each allergen is included in the COMPARE database with the supporting literature containing evidence of allergenicity. Both the process and the finalized, annually updated COMPARE database are publicly available on this website.
- Laurent Beuf, Vilmorin et Cie
- Supratim Choudhuri, U.S. FDA
- Eva Gietl, KWS
- Paul Guevara, Univ. of Maryland / JIFSAN
- Rod Herman, Corteva Agriscience™
- Emir Islamovic, BASF
- John Kough, U.S. EPA
- Greg Ladics, DuPont
- Scott McClain, Syngenta
- Kyle McKillop, Univ. of Maryland / JIFSAN
- Henry Mirsky, Corteva Agriscience™
- Clare Narrod, Univ. of Maryland / JIFSAN
- Esmeralda Posada Campos, BASF
- Andre Silvanovich, Bayer
- Ping Song, Corteva Agriscience™
- Afua Tetteh, BASF
- Ronald van Ree, Academic Medical Center, University of Amsterdam
- Gao Zhongshan, Zhejiang University, China
Peer Review Panel
- Gabriele Gadermaier, PhD, Paris-London University of Salzburg, Austria
- Karin Hoffman-Sommergruber, PhD, Medical University of Vienna, Austria
- Lars Poulsen, PhD, Copenhagen University Hospital, Denmark
- Suzanne Teuber, MD, University of California, Davis, CA, USA
- Ronald van Ree, PhD, Academic Medical Center, University of Amsterdam, The Netherlands
Past Peer Review Panelist
- Cecilia Berin, PhD, Icahn School of Medicine at Mount Sinai, NY, USA (for COMPARE 2017 and COMPARE 2018 versions)
HESI, the Health and Environmental Sciences Institute, is a non-profit, global scientific organization dedicated to developing science for a safer, more sustainable world.
HESI’s mission is to collaboratively identify and help to resolve global health and environmental challenges through engagement of scientists from academia, government, industry, NGOs, and other strategic partners.
HESI was established in 1989 to provide an international forum to advance the understanding of scientific issues related to human health, toxicology, risk assessment, and the environment.