Allergenicity Safety Assessment

Genetically engineered eucalyptus expressing pesticidal proteins from Bacillus thuringiensis for insect resistance: a risk assessment evaluation perspective. Frontiers in Bioengineering and Biotechnology. (Avisa et al., 2024)

Safety assessment of insecticidal proteins: A case study utilizing His-tagged protein to determine the safety of Mpp75Aa1.1, a new ETX_MTX2 protein that controls western corn rootworm.  BioRxiv Preprint. (Want et al., 2023)

Safety assessment of Mpp75Aa1.1, a new ETX_MTX2 protein from Brevibacillus laterosporus that controls western corn rootworm. PLOS ONE. (Wang et al., 2022)

Safety assessment of the insecticidal protein IPD079Ea from the fern, Ophioglossum pendulum. Food Chem Toxicol. (Carlson et al.,  2022)

Biochemical and clinical studies of putative allergens to assess what distinguishes them from other non-allergenic proteins in the same family. Transgenic Research. (Glenn et al., 2022)

Comprehensive COMPARE database reduces allergenic risk of novel food proteins. GM Crops & Food. (Herman RA & Song P., 2022)

Allergen Databases

The updated Structural Database of Allergenic Proteins (SDAP 2.0) provides 3D models for allergens and incorporated bioinformatics tools. J Allergy Clin Immunol Glob. (Negi et al., 2023)

Les bases de données en allergologie moléculaire. Databases in molecular allergy. Revue Francaise d'Allergologie. (Klingebiel et al., 2022)

Still SDAPing Along: 20 Years of the Structural Database of Allergenic Proteins.  Frontiers in Allergy. (Schein et al., 2022)

GMO-db: Comprehensive database on biotechnology products. National Institute of Health Sciences (NIHS), Division of Biochemistry. COMPARE cited in section on Allergenicity assessment of biotechnology products as a database capable of implementing the FAO/WHO allergenicity prediction method.

Allergenicity Prediction Tools

PreAlgPro: Prediction of allergenic proteins with pre-trained protein language model and efficient neutral network. International Journal of Biological Macromolecules. (Zhang and Liu, 2024)

Chapter 9 - Tools and platform for allergenicity prediction. Reverse Vaccinology. (Mishra & Georrge, 2024)

Novel strategies for predicting allergenicity: development of a ranking method and screening tools to assess the allergy risk of innovative proteins. EFSA Supporting Publications. (Mills et al., 2024)

pLM4Alg: Protein Language Model-Based Predictors for Allergenic Proteins and Peptides. J Agric Food Chem. (Du et al., 2023)

DeepAlgPro: an interpretable deep neural network model for predicting allergenic proteins. Briefings in Bioinformatics. (He et al., 2023)

NetAllergen, a random forest model integrating MHC-II presentation propensity for improved allergenicity prediction. Bioinformatics Advances. (Li et al., 2023)

ALLERDET: A novel web app for prediction of protein allergenicity. Journal of Biomedical Informatics. (Garcia-Moreno & Gutiérrez-Naranjo, 2022)

AllerCatPro—prediction of protein allergenicity potential from the protein sequence. Bioinformatics. (Maurer-Stroh et al., 2019)

Allergy Detection Methods and Bioinformatics

Food allergen detection by mass spectrometry: From common to novel protein ingredients. Proteomics. (Bianco et al., 2023)

Advanced Proteomic and Bioinformatic Tools for Predictive Analysis of Allergens in Novel Foods. Biology. (Lopez-Pedrouso et al., 2023)

Novel Machine Learning Method AllerStat Identifies Statistically Significant Allergen-Specific Patters in Protein Sequences. J Biol Chem. (Goto et al., 2023)

Investigating phenotypic relationships in persimmon accessions through integrated proteomic and metabolomic analysis of corresponding fruits. Frontiers in Plant Sciences. (De Pascale et al., 2023)

Predicting the allergenic risk of Phosphite-NAD+-Oxidoreductase and purple acid phosphatase 17 proteins in genetically modified canola using bioinformatic approaches. Food and Chemical Toxicology. (Zamani et al., 2023)

“From Protein Toxins to Applied Toxicological Testing” virtual workshop identifies the need for a bioinformatic framework to assess novel food protein safety. Regulatory Toxicology and Pharmacology. (Bauman et al., 2022)

Potential allergenicity of Medicago sativa investigated by a combined IgE-binding inhibition, proteomics and in silico approach. Journal of the Science of Food and Agriculture. (Yakhelf et al., 2020)

Allergy Reviews

Can Physicochemical Properties Alter the Potency of Aeroallergens? Part 1 – Aeroallergen Protein Families.  Current Allergy and Asthma Reports. (Teixeira et al., 2024)

A systematic review of allergen cross-reactivity: Translating basic concepts into clinical relevance. The Journal of Allergy and Clinical Immunology. (Sharma et al., 2024)

Food allergen analysis: A review of current gaps and the potential to fill them by matrix-assisted laser desorption/ionization. Comprehensive Reviews in Food Science and Food Safety. (Birse et al., 2023)

Molecular Allergology User's Guide 2.0.  European Academy of Allergy and Clinical Immunology. EBook (2022)

How Do Pollen Allergens Sensitize? Frontiers in Molecular Biosciences. (Guryanova et. al., 2022)

Cross-Reactivity and Molecular Allergology

In silico approaches to identifying potentially cross-reactive allergens. Encyclopedia of Food Allergy (Chapter). (Richard Goodman, 2024)

Food-Pollen Cross-Reactivity and its Molecular Diagnosis in China. Current Allergy and Asthma Reports. (Zhao et al., 2024)

Crosstalk Between the Immune System and Plant-Derived Nanovesicles: A Study of Allergen Transporting. Front. Bioeng. Biotechnol. (Stanly et al., 2021)

Regulatory and Risk Assessment

Allergic to bureaucracy? Regulatory allergenicity assessments of novel food: Motivations, challenges, compromises, and possibilities. Comprehensive Reviews in Food Science and Food Safety. (Kedar et al., 2024)

Flexibility and amendments of the Codex Alimentarius aimed towards small food business entities. Meat Technology. (Mrdovć et al,. 2023)

Sustainable Food Systems: EU Regulatory Framework and Contribution of Insects to the Farm-To-Fork Strategy.  Food Reviews International. (Delgado et al., 2022)

Slow alignment of GMO allergenicity regulations with science on protein digestibility. GM Crops & Food. (Herman et al., 2022)

Other

Extracellular Vesicles Are Prevalent and Effective Carriers of Environmental Allergens in Indoor Dust. Environmental Science & Technology. Long et al., 2024.

THPdb2: compilation of FDA approved therapeutic peptides and proteins. Drug Discovery Today. Jain et. al., 2024.

Development of a pharmaceutical database as an aid to the nonclinical detection of drug-induced cardiac toxicity.  Journal of Pharmacological and Toxicological Methods. De Alwis et al., 2024.

Efficient genetic transformation of rice using Agrobacterium with a codon-optimized chromoprotein reporter gene (ChromoP) and introducing an optimized iPCR method for transgene integration site detection. Plant Cell, Tissue and Organ Culture. Mohasses et al., 2023.

Trehalose Phosphorylase as a Novel Potential Allergen in a Case of Allergic Reaction due to Oyster Mushroom (Pleurotus ostreatus) Ingestion.  Journal of Allergy and Clinical Immunology: Global. Rangkakulnuwat et al., 2023.

Unbiased prediction of off‐target sites in genome‐edited rice using SITE‐Seq analysis on a web‐based platform. Genes to Cells. Narushima et al., 2022.