The COMprehensive Protein Allergen REsource is a new comprehensive repository of protein sequences of known or putative allergens.  It was created via the development of an automated “rule-based” sorting algorithm tool, combined with a review of the literature associated with the identified sequences.  An independent peer-review panel of allergy experts exclusively from the public sector decides on the final content of the database. These three rigorous and well-documented processes have been carefully designed to meet the needs for allergy safety assessment. The combination of these three processes has resulted in the new COMPARE database released on 16 February 2018. The database includes a comprehensive repository of all known allergens, with the addition of newly identified allergens. The cycle will repeat annually for regular updates. This approach will:

1) Identify new listings of candidate allergen sequences.

2) Identify published literature linked to the identified potential allergens. 

3) Verify that the newly identified sequences have clinical evidence of allergenicity based on standardized criteria.


Program Structure

The COMPARE database is a collaborative effort of the HESI (Health and Environmental Sciences Institute) Protein Allergenicity Technical Committee (PATC). The PATC is a public-private collaboration of scientists with a shared interest in improving the assessment of allergenicity in the context of safety evaluation of novel food and feed proteins.

The COMPARE team combines programmatic support from the Joint Institute for Food Safety and Nutrition (http://jifsan.umd.edu) at the University of Maryland, and significant in-kind support from multiple academic, government and industry scientists with expertise in protein allergenicity. This public-private HESI collaborative team has documented database design and search algorithm decisions on this website.  For 2018 the external expert panel reviewed protein sequences identified as potential allergens using peer-reviewed publications to determine if they meet criteria for inclusion in the database. In a fully transparent manner, the expert panel documented the supporting data for each verified allergen and each allergen was included in the COMPARE database. Both the process and the finalized, annually updated COMPARE database are publicly available on this website.

Steering Team 

  • Katie Bailey, Syngenta
  • Laurent Beuf, Vilmorin et Cie
  • Supratim Choudhuri, US FDA
  • Eva Gietl, KWS
  • Paul Guevara, Univ. of Maryland / JIFSAN
  • Rod Herman, Dow
  • Emir Islamovic, BASF
  • John Kough, U.S. EPA
  • Greg Ladics, Dupont
  • Scott McClain, Syngenta
  • Kyle McKillop, Univ. of Maryland / JIFSAN
  • Henry Mirsky, Dupont
  • Clare Narrod, Univ. of Maryland / JIFSAN
  • Esmeralda Posada Campos, Bayer
  • Rakesh Ranjan, Bayer
  • Andre Silvanovich, Monsanto
  • Ping Song, Dow
  • Ronald van Ree, Academic Medical Center, University of Amsterdam 


Peer Review Panel

  • Cecilia Berin, PhD, Icahn School of Medicine at Mount Sinai, NY, USA
  • Karin Hoffman-Sommergruber, PhD, Medical University of Vienna, Austria
  • Lars Poulsen, PhD, Copenhagen University Hospital, Denmark
  • Suzanne Teuber, MD, University of California, Davis, CA, USA
  • Ronald van Ree, PhD, Academic Medical Center, University of Amsterdam, The Netherlands 

About HESI

HESI, the Health and Environmental Sciences Institute, is a non-profit, global scientific organization dedicated to developing science for a safer, more sustainable world. 

HESI’s mission is to collaboratively identify and help to resolve global health and environmental challenges through engagement of scientists from academia, government, industry, NGOs, and other strategic partners.

HESI was established in 1989 as a global branch of the International Life Sciences Institute (ILSI) to provide an international forum to advance the understanding of scientific issues related to human health, toxicology, risk assessment, and the environment. In 2002, HESI was recognized by the United States government as a publicly supported, tax-exempt organization, independently chartered from ILSI.